Everyone Healthy Library
Familial Adenomatous Polyposis
Condition / disease reference page from the Everyone Healthy database.
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Connected health information
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Condition overview
Attributes
Commonalityis rare
Linked signs and symptoms
6Each sign/symptom opens its own page and links back to related conditions.
Linked drugs / medications
1Medication information is educational only. A doctor or pharmacist should advise whether any medicine is appropriate.
Treatments, therapies and supportive options
4Grouped by treatment type. These are educational database links, not personal treatment recommendations. Evidence labels are shown only where stored in the EH database.
Linked diagnostic tests and investigations
5These are pulled from both EH diagnostic-test link tables, including the older large test-link table.
Biological markers/agents
2This visual map shows biological markers/agents reported as increased or decreased with this condition. These are educational relationships only; test results must be interpreted by a qualified clinician because ranges vary by lab, method, age, sex and clinical context.
Introduction / full article
Familial Adenomatous Polyposis
Familial Adenomatous Polyposis
This is an inherited disorder that develops in the colon. Hundreds and thousands of polyps (which are abnormal tissue growths) accumulate and when untreated can cause colon cancer. The development of Familial Adenomatous Polyposis can start in the teenage years, while its projection to colon cancer usually does not start until about 35 years of age. Symptoms include fatigue, abdominal pain, colonic bleeding, bloating, and diarrhoea but not all with Familial Adenomatous Polyposis will experience them. It is very important for those who have someone in the family with Familial Adenomatous Polyposis to be tested regularly and as early as possible.
Efficacy of Alternative and Other Treatments According to GRADE* Ranking:
Vitamin D [1, 2, 3, 4, 5, 6, 7, 8, 9, 10]:
Please note, this management does NOT treat the condition itself. It may mildly help in preventing some of the symptoms, and even then has insufficient evidence to back up this claim at present. Please note, this acts as a PREVENTATIVE treatment, and not necessarily symptomatic relief.
Recommendation: Weakly in favor (Observational studies show that a higher intake of Vitamin D may help lower the risk of getting Familial Adenomatous Polyposis. However, clinical trials need to be completed to provide more reliable evidence.)
Grade of Evidence: low quality of evidence
Calcium Gluconate:
Please note, this management does NOT treat the condition itself. It is proposed only as a preventative or supportive management, not as a treatment.
Recommendation: strongly in favor (Calcium supplements are effective in preventing Familial Adenomatous Polyposis)
Grade of Evidence: moderate quality of evidence
Calcium Supplements:
Please note, this management does NOT treat the condition itself. It is proposed only as a preventative or supportive management, not as a treatment.
Recommendation: strongly in favor (Calcium supplements are effective in preventing Familial Adenomatous Polyposis)
Grade of Evidence: moderate quality of evidence
* www.gradeworkinggroup.org
Summary References
Treatments:
1. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/vitamin-d
2. http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD006164/frame.html
3. http://www.ncbi.nlm.nih.gov/pubmed/10824056
4. http://onlinelibrary.wiley.com/doi/10.1002/jcb.10338/abstract
5. http://pain-topics.org/pdf/vitamind-report.pdf
6. http://informahealthcare.com/doi/abs/10.1185/030079908X253519
7. http://www.theglobeandmail.com/life/article756975.ece
8. http://www.ncbi.nlm.nih.gov/pubmed/17556697
9. http://www.ncbi.nlm.nih.gov/pubmed/18065602
10. http://www.nlm.nih.gov/medlineplus/vitamind.html