Everyone Healthy Library
Hereditary Vitamin D Dependent Rickets
Condition / disease reference page from the Everyone Healthy database.
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Connected health information
Explore this condition in a clear order
Condition overview
Attributes
Ageis Child
Linked signs and symptoms
4Each sign/symptom opens its own page and links back to related conditions.
Linked drugs / medications
1Medication information is educational only. A doctor or pharmacist should advise whether any medicine is appropriate.
Treatments, therapies and supportive options
7Grouped by treatment type. These are educational database links, not personal treatment recommendations. Evidence labels are shown only where stored in the EH database.
Vitamins and minerals
3Vitamins
1Minerals
2Linked diagnostic tests and investigations
4These are pulled from both EH diagnostic-test link tables, including the older large test-link table.
Biological markers/agents
4This visual map shows biological markers/agents reported as increased or decreased with this condition. These are educational relationships only; test results must be interpreted by a qualified clinician because ranges vary by lab, method, age, sex and clinical context.
Often increased
2- Alkaline Phosphatase (ALP)Reference range exampleAdult ( > 16y), Female: 30–125 units/L; Adult ( > 16y), Male: 40–110 units/LLinked diagnostic testsAlkaline Phosphatase (ALP) Concentration
- Parathyroid hormone (PTH, Parathormone)Reference range exampleAdult ( > 16y): 10–62 pg/mLLinked diagnostic testsParathyroid Hormone Concentration
Often decreased
2- Calcium (Blood, Total)Reference range exampleAdult ( > 16y): 8.5–10.4 mg/dL; Birth - 2wks: 7.6–10.3 mg/dLLinked diagnostic testsCalcium Concentration (Blood, Total)
- Phosphate (PO4, Phosphorus, P)Reference range exampleAdult ( > 16y): 2.5–4.5 mg/dL; Birth - 2wks: 4.3–9.2 mg/dLLinked diagnostic testsPhosphate Concentration (PO4, Phosphorus)
Introduction / full article
Hereditary Vitamin D Dependent Rickets
Efficacy of Alternative and Other Treatments According to GRADE* Ranking:
Vitamin D [1, 2, 3, 4, 5, 6, 7, 8, 9, 10]:
Please note, this management does NOT treat the condition itself. It may mildly help in preventing some of the symptoms, and even then has insufficient evidence to back up this claim at present. Please note, this acts as a PREVENTATIVE treatment, and not necessarily symptomatic relief.
Recommendation: strongly in favor (Studies have shown that a Vitamin D can help to prevent and treat rickets)
Grade of Evidence: high quality of evidence
Calcium Supplement [11, 12, 13, 14]:
Please note, this management does NOT treat the condition itself. It may mildly help in preventing some of the symptoms, and even then has insufficient evidence to back up this claim at present. Please note, this acts as a PREVENTATIVE treatment, and not necessarily symptomatic relief.
Recommendation: strongly in favor (Studies show that calcium supplements may be beneficial to those with rickets)
Grade of Evidence: high quality of evidence
Phosphate Supplements [15, 16]:
Please note, this management does NOT treat the condition itself. It may mildly help in preventing some of the symptoms, and even then has insufficient evidence to back up this claim at present. Please note, this acts as a PREVENTATIVE treatment, and not necessarily symptomatic relief.
Recommendation: weakly in favor (Early studies show that phosphate supplements may be able to help those with rickets. Further studies are needed)
Grade of Evidence: low quality of evidence
* www.gradeworkinggroup.org
Summary References
Treatments:
1. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/vitamin-d
2. http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD006164/frame.html
3. http://www.ncbi.nlm.nih.gov/pubmed/10824056
4. http://onlinelibrary.wiley.com/doi/10.1002/jcb.10338/abstract
5. http://pain-topics.org/pdf/vitamind-report.pdf
6. http://informahealthcare.com/doi/abs/10.1185/030079908X253519
7. http://www.theglobeandmail.com/life/article756975.ece
8. http://www.ncbi.nlm.nih.gov/pubmed/17556697
9. http://www.ncbi.nlm.nih.gov/pubmed/18065602
10. http://www.nlm.nih.gov/medlineplus/vitamind.html
11. http://ajcn.nutrition.org/content/80/6/1725S.full
12. http://www.ncbi.nlm.nih.gov/pubmed/15585795
13. http://www.nature.com/bonekeyreports/2014/140319/bonekey201419/full/bonekey201419.html
14. https://clinicaltrials.gov/ct2/show/NCT01578434
15. http://www.endocrineconnections.com/content/3/1/R13.full
16. http://www.ncbi.nlm.nih.gov/pubmed/6259210