Everyone Healthy Library
Neonatal Herpes Simplex Virus Infection
Condition / disease reference page from the Everyone Healthy database.
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Connected health information
Explore this condition in a clear order
Condition overview
Attributes
Ageis Infant
Commonalityis rare
Linked signs and symptoms
13Each sign/symptom opens its own page and links back to related conditions.
Linked drugs / medications
1Medication information is educational only. A doctor or pharmacist should advise whether any medicine is appropriate.
Treatments, therapies and supportive options
8Grouped by treatment type. These are educational database links, not personal treatment recommendations. Evidence labels are shown only where stored in the EH database.
Alternative medicine
4Linked diagnostic tests and investigations
25These are pulled from both EH diagnostic-test link tables, including the older large test-link table.
- Alpha-1 Antitrypsin (AAT) Concentration
- Cerebrospinal Fluid Albumin Concentration
- Cerebrospinal Fluid Protein Concentration
- Cerebrospinal Fluid Protein Electrophoresis
- Cerebrospinal Fluid White Cell Differential
- Cholesterol Concentration
- D-Dimer Blood Test
- Ferritin Concentration
- Fibrin Degradation Products (FDPs, Fibrin Split Products, FSPs, Fibrin Breakdown Products, Fbps)
- Fibrin Monomers Test
- Fibrinogen Concentration test
- Fibrinopeptide A (FPA) Action Assay
- Glucagon Concentration Test
- Glucose 6 Phosphate Dehydrogenase (G6PD) Concentration
- Glucose, Blood (Random Blood Glucose Test)
- haptoglobin (Hp) concentration
- Lymphocyte Immunophenotyping
- Monocyte Absolute Count
- Neutrophil Absolute Count
- Plasminogen Activity
- Platelet Count
- Potassium Concentration (K, Blood)
- Protein Electrophoresis (Blood, Serum Protein)
- Urine glucose concentration
- White Blood Cell (WBC) Count
Biological markers/agents
29This visual map shows biological markers/agents reported as increased or decreased with this condition. These are educational relationships only; test results must be interpreted by a qualified clinician because ranges vary by lab, method, age, sex and clinical context.
Often increased
21- Albumin (Cerebrospinal Fluid, CSF)Reference range exampleAll: 10–35 mg/dL; All: 56–76 %Linked diagnostic testsCerebrospinal Fluid Albumin Concentration, Cerebrospinal Fluid Protein Electrophoresis
- Alpha-1 Antintrypsin (AAT)Reference range exampleAdult ( > 16y): 90–215 mg/dLLinked diagnostic testsAlpha-1 Antitrypsin (AAT) Concentration
- Alpha-1-Globulin (Blood, Serum)Reference range exampleAll: 0.1–0.3 gm/dLLinked diagnostic testsProtein Electrophoresis (Blood, Serum Protein)
- Alpha-2-Globulin (Blood, Serum)Reference range exampleAll: 0.6–1 gm/dLLinked diagnostic testsProtein Electrophoresis (Blood, Serum Protein)
- Cerebrospinal Fluid LeukocytesReference range exampleAdult ( > 16y): 0–5 /µL; 1y - 6y: 0–20 /µLLinked diagnostic testsCerebrospinal Fluid White Cell Differential
- Cerebrospinal Fluid Total ProteinReference range exampleAdult ( > 16y): 15–45 mg/dL; Child (< 10y): 15–70 mg/dLLinked diagnostic testsCerebrospinal Fluid Protein Concentration
- Cholesterol (Total)Reference range exampleInfant (0 - 1y): 75–180 mg/dL; Adult ( > 16y): 0–190 mg/dLLinked diagnostic testsCholesterol Concentration
- D-DimerReference range exampleAdult ( > 16y): 0–240 µg/LLinked diagnostic testsD-Dimer Blood Test
- FerritinReference range exampleChild (0 - 16y): 7–140 µg/L; Adult ( > 16y), Female: 18–160 µg/LLinked diagnostic testsFerritin Concentration
- Fibrin MonomersReference range example0–10,000 µg/LLinked diagnostic testsFibrin Monomers Test
- Fibrin Split ProductsReference range exampleAll: 0–1 mg/dLLinked diagnostic testsFibrin Degradation Products (FDPs, Fibrin Split Products
- FibrinogenReference range exampleAdult ( > 16y): 150–400 mg/dLLinked diagnostic testsFibrinogen Concentration test
- Fibrinopeptide A (FPA)Reference range exampleAdult ( > 16y), Female: 0.7–3.1 mg/mL; Adult ( > 16y), Male: 0.35–2.5 mg/mLLinked diagnostic testsFibrinopeptide A (FPA) Action Assay
- GlucagonReference range exampleChild (0 - 16y): 0–147 pg/mL; Adult ( > 16y): 20–110 pg/mLLinked diagnostic testsGlucagon Concentration Test
- haptoglobin (Hp)Reference range example45–200 mg/dLLinked diagnostic testshaptoglobin (Hp) concentration
- MonocytesReference range exampleAdult ( > 16y): 3–7 %; 0.1–0.5 million/mLLinked diagnostic testsDifferential White Blood Cell Count Tests, Monocyte Absolute Count
- PlasminogenReference range exampleAdult ( > 16y), Female: 65–153 %; Adult ( > 16y), Male: 70–120 %Linked diagnostic testsPlasminogen Activity
- Potassium (K, Blood)AbbreviationKReference range exampleInfant (0 - 1y): 4.1–5.3 mEq/L; Child (0 - 16y): 3.4–4.7 mEq/LLinked diagnostic testsPotassium Concentration (K, Blood)
- PrealbuminReference range exampleAll: 2–7 %Linked diagnostic testsCerebrospinal Fluid Protein Electrophoresis
- Urine glucoseReference range example0–2.5; Adult ( > 16y): 0–2.5 mmol/dayLinked diagnostic testsUrine glucose concentration
- White Blood Cell (WBC)Reference range exampleAdult ( > 16y): 4.5–10.5 million/mL; Adult ( > 16y): 3.2–10 million/mLLinked diagnostic testsWhite Blood Cell (WBC) Count
Often decreased
8- Glucose (Blood)Reference range exampleInfant (0 - 1y): 3–6.1 mmol/L; Adult ( > 16y): 0–6.1 mmol/LLinked diagnostic testsfasting Blood Glucose Test, Glucose Tolerance Test (GTT
- Glucose 6 Phosphate Dehydrogenase (G6PD)Reference range exampleAdult ( > 16y): 10.1–18.5 U/gHb; Birth - 2wks: 12–23 U/gHbLinked diagnostic testsGlucose 6 Phosphate Dehydrogenase (G6PD) Concentration
- Helper T cells (CD3(plus), CD4(plus))Reference range example589–1,505 cells/mm3; 32–61Linked diagnostic testsHelper T cells (CD3(plus), CD4(plus)) Count
- Natural Killer Cells (CD16 Percentage)Reference range exampleAll: 4–30 %Linked diagnostic testsLymphocyte Immunophenotyping
- PlateletsReference range exampleChild (0 - 16y): 150–450 109/L; Adult ( > 16y): 135–380 109/LLinked diagnostic testsPlatelet Count
- Segmented NeutrophilsReference range exampleAdult ( > 16y): 50–62 %; Adult ( > 16y): 2,500–8,000 mm3Linked diagnostic testsDifferential White Blood Cell Count Tests, Neutrophil Absolute Count
- T-Suppressor (CD8) CellsReference range exampleAll: 15–40 %Linked diagnostic testsLymphocyte Immunophenotyping
- Total T cells (CD3(plus))Reference range exampleAll: 55–90 %; 812–2,318 cells/mm3Linked diagnostic testsLymphocyte Immunophenotyping, Total T Cells (CD3(plus)) Count
Introduction / full article
Neonatal Herpes Simplex Virus Infection
Efficacy of Alternative and Other Treatments According to GRADE* Ranking:
Gotu Kola (Centella Asiatica, Hydrocotyle Asiatica)[1, 12, 13, 14, 15, 16, 17]:
Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present.
Recommendation: no recommendation (There is insufficient evidence to support claims that Gotu Kola helps in the treatment of herpes in any way. More research is needed.)
Grade of Evidence: low quality of evidence
Goldenseal (Hydrastis Canadensis) [1, 5, 6, 7, 8, 9, 10, 11]:
Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present.
Recommendation: Weakly against (There is insufficient evidence to support claims that Goldenseal helps to treat herpes. More studies are needed. Goldenseal may produce toxic effects, including depression, constipation, rapid heartbeat, stomach pain, mouth ulcers and vomiting.)
Grade of Evidence: low quality of evidence
Celandine (Ukrain, Chelidonium Majus) [1, 3, 4]:
Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present.
Recommendation: weakly against (There is insufficient evidence that Celandine helps to cure or treat herpes. In addition, the plant is mildly poisonous to humans. It may cause hepatitis as well as symptoms of pain, nausea, thirst, and fever.)
Grade of Evidence: very low quality of evidence
Cats Claw (Uncaria Tomentosa) [1, 2]:
Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present.
Recommendation: no recomendation (insufficient evidence to support claims that Cats Claw can help to treat herpes)
Grade of Evidence: very low quality of evidence
* www.gradeworkinggroup.org
Summary References
Treatment:
1. Ades T, Alteri R, Gansler T, Yeargin P, "Complete Guide to Complimentary & Alternative Cancer Therapies", American Cancer Society, Atlanta USA, 2009
2. http://www.nutrasanus.com/cats-claw.html
3. http://abchomeopathy.com/r.php/Chel
4. http://www.naturalstandard.com/index-abstract.asp?create-abstract=/monographs/herbssupplements/greatercelandine.asp
5. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/goldenseal
6. http://nccam.nih.gov/health/goldenseal/
7. Tierra Michael (1998): The Way of Herbs. New York, Pocket Books
8. Grieve M. (1971): A Modern Herbal. New York, Dover Publications, Inc
9. Mills S. and Bone K. (2000): Principles and Practice of Phytotherapy. Philadelphia, Churchill Livingstone
10. Tice Raymond (1997): Goldenseal and Two of its constituent alkaloids: berberine and hydrastine Research Triangle Park, National Institute of Environmental Health Sciences, in Seiger E: Review of Toxilogical Literature
11. http://www.henriettesherbal.com/eclectic/ellingwood/hydrastis.html
12. Winston, D., Maimes, S., Adaptogens: Herbs For Strength, Stamina, and Stress Relief, 2007, pp. 226-7
13. "A Double-Blind, Placebo-Controlled Study on the Effects of Gotu Kola (Centella asiatica) on Acoustic Startle Response in Healthy Subjects". Journal of Clinical Psychopharmacology. 20(6):680-684, December 2000. Bradwejn, Jacques MD, FRCPC *; Zhou, Yueping MD, PhD ++; Koszycki, Diana PhD *; Shlik, Jakov MD, PhD
14. B. M. Hausen (1993) "Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer." Contact Dermatitis 29 (4), 175–179 doi:10.1111/j.1600-0536.1993.tb03532.x
15. Cataldo, A., Gasbarro, V., et al., "Effectiveness of the Combination of Alpha Tocopherol, Rutin, Melilotus, and Centella asiatica in The Treatment of Patients With Chronic Venous Insufficiency", Minerva Cardioangiology, 2001, Apr; 49(2):159-63
17. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/gotu-kola