Everyone Healthy medication library
Dopamine antagonist Drug Class
Medicines in this drug class are grouped together in the Everyone Healthy medication database. This page is educational only and should not be used as personal prescribing advice.
Drug class overview
Dopamine antagonist overview
Dopamine antagonist
A dopamine antagonist is a drug which blocks dopamine receptors by receptor antagonism. There are five known types of dopamine receptors in the human body; they are found in the brain, peripheral nervous system, blood vessels, and the kidney.
Uses and examples
- Used as atypical antipsychotics (coupled with serotonin antagonist effects): clozapine, risperidone, olanzapine, quetiapine, and ziprasidone
- Used as antiemetics: metoclopramide, droperidol, domperidone
- Used as tricyclic antidepressants: amoxapine
Side effects
- Parkinsonism - due to effects on the nigrostriatal pathway
- Hyperprolactinaemia - due to effects on the tuberoinfundibular pathway
- Tardive dyskinesia (long term use)
Examples
Other examples include:[1]
- acepromazine
- amisulpride
- amoxapine
- azaperone
- benperidol
- bromopride
- butaclamol
- chlorpromazine
- chlorprothixene
- clopenthixol
- domperidone
- droperidol
- eticlopride
- flupenthixol
- fluphenazine
- fluspirilene
- haloperidol
- loxapine
- mesoridazine
- levomepromazine
- metoclopramide
- nafadotride
- nemonapride
- penfluridol
- perazine
- perphenazine
- pimozide
- prochlorperazine
- promazine
- raclopride
- remoxipride
- risperidone
- spiperone
- spiroxatrine
- stepholidine
- sulpiride
- sultopride
- tetrahydropalmatine
- thiethylperazine
- thioridazine
- thiothixene
- tiapride
- trifluoperazine
- trifluperidol
- triflupromazine
- ziprasidone
References
External links
Linked medicines