Mucolytic agent

A mucolytic agent or expectorant is any agent which dissolves thick mucus and is usually used to help relieve respiratory difficulties. It does so by hydrolyzing glycosaminoglycans, tending to break down/lower the viscosity of mucin-containing body secretions/components. The viscosity of mucous secretions in the lungs is dependent upon the concentrations of mucoprotein, the presence of disulfide bonds between these macromolecules and DNA.

An expectorant (from the Latin expectorare, to expel from the chest) is a medication that helps bring up mucus and other material from the lungs, bronchi, and trachea. An example of an expectorant is guaifenesin which promotes drainage of mucus from the lungs by thinning the mucus and lubricating the irritated respiratory tract. Sometimes the term "expectorant" is incorrectly extended to any cough medicine.

"An expectorant increases bronchial secretions and mucolytics help loosen thick bronchial secretions. Expectorants reduce the thickness or viscosity of bronchial secretions thus increasing mucus flow that can be removed more easily through coughing, Mucolytics break down the chemical structure of mucus molecules. The mucus becomes thinner and can be removed more easily through coughing" (Adams, Holland, & Bostwick, 2008, p. 591).

References

• Adams, Holland, & Bostwick (2008). Pharmacology for Nurses: A Pathophysiologic approach. Author. Upper Saddle River, New Jersey.

External links

• Robert G. Aucoin RPh - Mucolytic Agents