Everyone Healthy medication library
Nitroimidazole Drug Class
Medicines in this drug class are grouped together in the Everyone Healthy medication database. This page is educational only and should not be used as personal prescribing advice.
Drug class overview
Nitroimidazole overview
Nitroimidazole
| 4-Nitroimidazole[1] | |
|---|---|
 |
|
| Identifiers | |
| CAS number | 3034-38-6 |
| PubChem | 18208 |
| SMILES | |
| Properties | |
| Molecular formula | C3H3N3O2 |
| Molar mass | 113.07 g/mol |
| Melting point |
303 °C (dec.) |
| Hazards | |
| R-phrases | R20/21/22 R36/37/38 |
| S-phrases | S26 S36/37 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
4-Nitroimidazole is an imidazole derivative which contains a nitro group.
Several derivatives of nitroimidazole constitute the class of nitroimidazole antibiotics which have been used to combat anaerobic bacterial and parasitic infections. Perhaps the most common example is metronidazole (Flagyl). Other heterocycles such as nitrothiazoles (thiazole) are also used for this purpose. Nitroheterocycles may be reductively activated in hypoxic cells, and then undergo redox recycling or decompose to toxic products.[2]
References
- ^ 4-Nitroimidazole at Sigma-Aldrich
- ^ Annu. Rev. Pharmacol. Toxicol. 29: 165–167. 1989.
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