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Everyone Healthy medication library

Polyenes Drug Class

Medicines in this drug class are grouped together in the Everyone Healthy medication database. This page is educational only and should not be used as personal prescribing advice.

Caution: A drug class groups medicines that may share similar actions or uses. Individual medicines in the same class can still have different cautions, interactions and suitability.

Drug class overview

Polyenes overview

Polyene

Polyenes are poly-unsaturated organic compounds that contain one or more sequences of alternating double and single carbon-carbon bonds. These double carbon-carbon bonds interact in a process known as conjugation, which results in an overall lower energy state of the molecule.

Organic compounds with two carbon-carbon double bonds are dienes; those with three such double bonds are trienes; those with four are tetraenes, etc.

Amphotericin B is an example of a yellow-colored polyene antifungal (antimycotic) agent. Note the alternating double and single bonds in the center.

Normally carbon-carbon double bonds which are not conjugated or only conjugated with only one or two other carbon-carbon double bonds have high enough energy that they absorb in the ultraviolet region of a spectrum, but the absorption energy state of polyenes with numerous conjugated double bonds can be lowered such that they enter the visible region of the spectrum, resulting in compounds which are colored yellow or other colors.

Many fatty acids are polyenes, and many dyes contain linear polyenes. Other examples of polyene compounds include beta-carotene, which is yellow to orange colored depending on concentration, and polyene antimycotics,[1] some of which are yellow colored.

References

^ NCBI Bookshelf (1996). "Polyene Antifungal Drugs". The University of Texas Medical Branch at Galveston. http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=mmed&part=A4050. Retrieved 29 January 2010.

Linked medicines

0 medicines in this class

No linked medicines were found for this drug class in the detected link table. The drug class exists, but the drug-class-to-medicine link table may need a table-name or column-name adjustment.