Everyone Healthy Library
Scleroderma Renal Disease
Condition / disease reference page from the Everyone Healthy database.
Connected health information
Explore this condition in a clear order
Linked signs and symptoms
19Each sign/symptom opens its own page and links back to related conditions.
- Anaemia (Anemia)
- Ankle Swelling (Ankle Oedema)
- Appetite Loss (Anorexia)
- Blood Pressure High (Hypertension)
- Breath Shortness (Dyspnoea)
- Breathing Painful or Difficult
- Fatigue
- Fluid Retention
- Lung Fluid Accumulation (Oedema Pulmonary)
- Mind: Malaise
- Nausea
- Pain Joint (Arthralgia)
- Skin Dry
- Skin Hardening
- Skin Itching Generalized
- Skin Redness (Erythema, Rubor)
- Skin Shiny
- Swelling (Oedema, Edema)
- Vomiting
Linked drugs / medications
0No linked drugs are listed yet.
Treatments, therapies and supportive options
8Grouped by treatment type. These are educational database links, not personal treatment recommendations. Evidence labels are shown only where stored in the EH database.
Surgery
2Medical therapy
3Alternative and complementary therapies
1Alternative medicine
1Linked diagnostic tests and investigations
9These are pulled from both EH diagnostic-test link tables, including the older large test-link table.
- Angiotensin Converting Enzyme (ACE) Concentration
- Fibrin Degradation Products (FDPs, Fibrin Split Products, FSPs, Fibrin Breakdown Products, Fbps)
- Fibrin Monomers Test
- Magnesium Concentration (Mg, Blood)
- Protein Electrophoresis (Blood, Serum Protein)
- Protein S Concentration
- Triglyceride (TGs) Concentration
- Urine Chloride Concentration
- Urine Lysozyme Concentration
Biological and test markers
11This visual map uses existing EH database links to show biological agents and lab markers reported as increased, decreased, or associated with this condition. These are educational relationships only; test results must be interpreted by a qualified clinician because ranges vary by lab, method, age, sex and clinical context.
Often increased
6- Angiotensin Converting Enzyme (ACE)Reference range exampleAll: 0–45 units/LLinked diagnostic tests1Angiotensin Converting Enzyme (ACE) Concentration
- Fibrin MonomersReference range example0–10,000 µg/LLinked diagnostic tests1Fibrin Monomers Test
- Fibrin Split ProductsReference range exampleAll: 0–1 mg/dLLinked diagnostic tests1Fibrin Degradation Products (FDPs, Fibrin Split Products
- Lysozyme (Muramidase, Urine)Reference range exampleAll: 0–4 mg/24hrsLinked diagnostic tests1Urine Lysozyme Concentration
- Magnesium (Mg, Blood)Reference range exampleAdult ( > 16y): 1.3–2.6 mEq/L; Birth - 2wks: 1.4–2.2 mEq/LLinked diagnostic tests1Magnesium Concentration (Mg, Blood)
- TriglyceridesReference range exampleAdult ( > 16y), Female: 32–137 mg/dL; Adult ( > 16y), Male: 35–155 mg/dLLinked diagnostic tests2Triglyceride (TG's) Concentration, Triglyceride (TGs) Concentration
Often decreased
5- Alpha-1-Globulin (Blood, Serum)Reference range exampleAll: 0.1–0.3 gm/dLLinked diagnostic tests1Protein Electrophoresis (Blood, Serum Protein)
- Alpha-2-Globulin (Blood, Serum)Reference range exampleAll: 0.6–1 gm/dLLinked diagnostic tests1Protein Electrophoresis (Blood, Serum Protein)
- Beta GlobulinReference range exampleAll: 0.7–1.2 gm/dLLinked diagnostic tests1Protein Electrophoresis (Blood, Serum Protein)
- Protein SReference range exampleAdult ( > 16y), Female: 50–120 %; Adult ( > 16y), Male: 55–120 %Linked diagnostic tests1Protein S Concentration
- Urine ChlorideReference range exampleInfant (0 - 1y): 2–10 mmol/day; Child (0 - 16y): 15–14 mmol/dayLinked diagnostic tests1Urine Chloride Concentration
Other associated markers
0No markers in this group.
Introduction / full article
Scleroderma Renal Disease
Efficacy of Alternative and Other Treatments According to GRADE* Ranking:
Gotu Kola (Centella Asiatica, Hydrocotyle Asiatica)[1, 2, 3, 4, 5, 6, 7]:
Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present.
Recommendation: Weakly in favor(A few clinical trials have shown that Gotu Kola may be helpful in the treatment of scleroderma. However, further research is needed)
Grade of Evidence: low quality of evidence
* www.gradeworkinggroup.org
Summary References
Treatments:
1. Ades T, Alteri R, Gansler T, Yeargin P, "Complete Guide to Complimentary & Alternative Cancer Therapies", American Cancer Society, Atlanta USA, 2009
2. Winston, D., Maimes, S., Adaptogens: Herbs For Strength, Stamina, and Stress Relief, 2007, pp. 226-7
3. "A Double-Blind, Placebo-Controlled Study on the Effects of Gotu Kola (Centella asiatica) on Acoustic Startle Response in Healthy Subjects". Journal of Clinical Psychopharmacology. 20(6):680-684, December 2000. Bradwejn, Jacques MD, FRCPC *; Zhou, Yueping MD, PhD ++; Koszycki, Diana PhD *; Shlik, Jakov MD, PhD
4. B. M. Hausen (1993) "Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer." Contact Dermatitis 29 (4), 175–179 doi:10.1111/j.1600-0536.1993.tb03532.x
5. Cataldo, A., Gasbarro, V., et al., "Effectiveness of the Combination of Alpha Tocopherol, Rutin, Melilotus, and Centella asiatica in The Treatment of Patients With Chronic Venous Insufficiency", Minerva Cardioangiology, 2001, Apr; 49(2):159-63
6. http://en.wikipedia.org/wiki/Gotu_kola#Medicinal_effects
7. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/gotu-kola