Everyone Healthy Library
Scleroderma Renal Disease
Condition / disease reference page from the Everyone Healthy database.
! Seek urgent medical care if warning signs appear
Some health conditions or symptoms can become urgent. Use this page for education, but seek help quickly if warning signs are present.
Get urgent medical care now if there is any severe, sudden, rapidly worsening or worrying symptom, especially:
- chest pain, pressure or pain spreading to the arm, jaw or back
- trouble breathing, blue lips, severe wheeze or choking
- stroke-like symptoms such as face drooping, arm weakness or speech trouble
- collapse, fainting, seizure, confusion or extreme drowsiness
- severe bleeding, black stools, vomiting blood or major injury
- severe allergic reaction, swelling of the face/throat or widespread rash with breathing trouble
- severe abdominal pain, severe headache, stiff neck or sudden vision change
- signs of severe dehydration, sepsis, high fever with worsening illness, or symptoms in a baby/young child that concern you
Connected health information
Explore this condition in a clear order
Linked signs and symptoms
19Each sign/symptom opens its own page and links back to related conditions.
- Anaemia (Anemia)
- Ankle Swelling (Ankle Oedema)
- Appetite Loss (Anorexia)
- Blood Pressure High (Hypertension)
- Breath Shortness (Dyspnoea)
- Breathing Painful or Difficult
- Fatigue
- Fluid Retention
- Lung Fluid Accumulation (Oedema Pulmonary)
- Mind: Malaise
- Nausea
- Pain Joint (Arthralgia)
- Skin Dry
- Skin Hardening
- Skin Itching Generalized
- Skin Redness (Erythema, Rubor)
- Skin Shiny
- Swelling (Oedema, Edema)
- Vomiting
Linked drugs / medications
0No linked drugs are listed yet.
Treatments, therapies and supportive options
8Grouped by treatment type. These are educational database links, not personal treatment recommendations. Evidence labels are shown only where stored in the EH database.
Surgery
2Medical therapy
3Alternative and complementary therapies
1Alternative medicine
1Linked diagnostic tests and investigations
9These are pulled from both EH diagnostic-test link tables, including the older large test-link table.
- Angiotensin Converting Enzyme (ACE) Concentration
- Fibrin Degradation Products (FDPs, Fibrin Split Products, FSPs, Fibrin Breakdown Products, Fbps)
- Fibrin Monomers Test
- Magnesium Concentration (Mg, Blood)
- Protein Electrophoresis (Blood, Serum Protein)
- Protein S Concentration
- Triglyceride (TGs) Concentration
- Urine Chloride Concentration
- Urine Lysozyme Concentration
Biological markers/agents
11This visual map shows biological markers/agents reported as increased or decreased with this condition. These are educational relationships only; test results must be interpreted by a qualified clinician because ranges vary by lab, method, age, sex and clinical context.
Often increased
6- Angiotensin Converting Enzyme (ACE)Reference range exampleAll: 0–45 units/LLinked diagnostic testsAngiotensin Converting Enzyme (ACE) Concentration
- Fibrin MonomersReference range example0–10,000 µg/LLinked diagnostic testsFibrin Monomers Test
- Fibrin Split ProductsReference range exampleAll: 0–1 mg/dLLinked diagnostic testsFibrin Degradation Products (FDPs, Fibrin Split Products
- Lysozyme (Muramidase, Urine)Reference range exampleAll: 0–4 mg/24hrsLinked diagnostic testsUrine Lysozyme Concentration
- Magnesium (Mg, Blood)Reference range exampleAdult ( > 16y): 1.3–2.6 mEq/L; Birth - 2wks: 1.4–2.2 mEq/LLinked diagnostic testsMagnesium Concentration (Mg, Blood)
- TriglyceridesReference range exampleAdult ( > 16y), Female: 32–137 mg/dL; Adult ( > 16y), Male: 35–155 mg/dLLinked diagnostic testsTriglyceride (TG's) Concentration, Triglyceride (TGs) Concentration
Often decreased
5- Alpha-1-Globulin (Blood, Serum)Reference range exampleAll: 0.1–0.3 gm/dLLinked diagnostic testsProtein Electrophoresis (Blood, Serum Protein)
- Alpha-2-Globulin (Blood, Serum)Reference range exampleAll: 0.6–1 gm/dLLinked diagnostic testsProtein Electrophoresis (Blood, Serum Protein)
- Beta GlobulinReference range exampleAll: 0.7–1.2 gm/dLLinked diagnostic testsProtein Electrophoresis (Blood, Serum Protein)
- Protein SReference range exampleAdult ( > 16y), Female: 50–120 %; Adult ( > 16y), Male: 55–120 %Linked diagnostic testsProtein S Concentration
- Urine ChlorideReference range exampleInfant (0 - 1y): 2–10 mmol/day; Child (0 - 16y): 15–14 mmol/dayLinked diagnostic testsUrine Chloride Concentration
Introduction / full article
Scleroderma Renal Disease
Efficacy of Alternative and Other Treatments According to GRADE* Ranking:
Gotu Kola (Centella Asiatica, Hydrocotyle Asiatica)[1, 2, 3, 4, 5, 6, 7]:
Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present.
Recommendation: Weakly in favor(A few clinical trials have shown that Gotu Kola may be helpful in the treatment of scleroderma. However, further research is needed)
Grade of Evidence: low quality of evidence
* www.gradeworkinggroup.org
Summary References
Treatments:
1. Ades T, Alteri R, Gansler T, Yeargin P, "Complete Guide to Complimentary & Alternative Cancer Therapies", American Cancer Society, Atlanta USA, 2009
2. Winston, D., Maimes, S., Adaptogens: Herbs For Strength, Stamina, and Stress Relief, 2007, pp. 226-7
3. "A Double-Blind, Placebo-Controlled Study on the Effects of Gotu Kola (Centella asiatica) on Acoustic Startle Response in Healthy Subjects". Journal of Clinical Psychopharmacology. 20(6):680-684, December 2000. Bradwejn, Jacques MD, FRCPC *; Zhou, Yueping MD, PhD ++; Koszycki, Diana PhD *; Shlik, Jakov MD, PhD
4. B. M. Hausen (1993) "Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer." Contact Dermatitis 29 (4), 175–179 doi:10.1111/j.1600-0536.1993.tb03532.x
5. Cataldo, A., Gasbarro, V., et al., "Effectiveness of the Combination of Alpha Tocopherol, Rutin, Melilotus, and Centella asiatica in The Treatment of Patients With Chronic Venous Insufficiency", Minerva Cardioangiology, 2001, Apr; 49(2):159-63
6. http://en.wikipedia.org/wiki/Gotu_kola#Medicinal_effects
7. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/gotu-kola